TCG Lifesciences has been catalyzing drug discovery efforts of its global life sciences client base over the past 15 years. It offers a range of customized in vitro ADME and Pharmacokinetics/Bioanalytical services at cost effective prices to speed up your SAR and discovery programs. Our flexible and responsive scientific team seamlessly adds value to your discovery efforts by providing consistent and accurate data with quick turnaround time and critical scientific inputs. 
   
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Solution Properties
Aqueous Solubility-Kinetic Aqueous Solubility-Equilibrium Chemical Stability
LogD LogP & pKa
   
 
Absorption / Distribution
PAMPA CACO-2 permeability MDCK-II permeability
Transporter Assay using Caco-2 Plasma Protein Binding Brain Tissue Binding
Blood to Plasma Ratio
   
 
Metabolism
Plasma Stability Metabolic Stability: Liver Microsomes Metabolic Stability: Liver S9
Metabolic Stability: Hepatocytes Recombinant CYP Inhibition - Fluorescence Detection CYP Inhibition using HLM; LC-MS/MS Detection
Time Dependant CYP Inhibition using HLM; LC-MS/MS Detection Metabolite Identification
   
 
Others
UGT based Metabolism using HLM PAMPA for Blood Brain Barrier hERG Binding
   
 
 
 

 
   
 
Contact Us
Chemistry:
mailto:bd@tcgls.com

cGMP Kilo Scale Synthesis:
scaleup@tcgls.com

Preclinical Discovery & Platform Technologies:
brlresearch@chembiotek.com